abstract：OBJECTIVES:To study the short term effects of a single dose of D2E7, a fully human anti-tumour necrosis factor (TNFalpha) monoclonal antibody (mAb), on the local and systemic homeostasis of interleukin 1beta (IL1beta) and TNFalpha in patients with rheumatoid arthritis (RA). METHODS:All patients with RA enrolled in a p...

journal_title：Annals of the rheumatic diseases

authors： Barrera P,Joosten LA,den Broeder AA,van de Putte LB,van Riel PL,van den Berg WB

更新日期：2001-07-01 00:00:00

abstract：:A 46 year old man presented with a growing mass over his wrist. Erosions of the triquetrum and hamate were present radiographically. Magnetic resonance imaging (MRI) showed a solid mass arising from the extensor carpi ulnaris tendon, which was T(1) hypointense and isointense, T(2) hypointense, and bloomed on gradient ...

journal_title：Annals of the rheumatic diseases

authors： Peh WC,Shek TW,Ip WY

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:To determine whether the humoral anti-chlamydia antibody response might be related to the ineffective bacterial elimination seen in patients with Chlamydia trachomatis reactive arthritis, particularly in men, who have a higher prevalence of the disease than women. METHODS:The number and specificity of the an...

journal_title：Annals of the rheumatic diseases

authors： Bas S,Scieux C,Vischer TL

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:To investigate polymorphisms of both codon 54 allele and promoter variants of the mannose binding lectin (MBL) gene in patients with primary Sjögren's syndrome (SS). METHODS:Polymorphisms of codon 54 allele and promoter variants of the MBL gene in 104 patients with SS and 143 healthy controls were determined...

journal_title：Annals of the rheumatic diseases

authors： Wang ZY,Morinobu A,Kanagawa S,Kumagai S

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:To study the demographic and clinical characteristics of patients with antiphospholipid syndrome (APS) with serious haemorrhagic complications of anticoagulant treatment in an attempt to establish risk factors for bleeding. METHODS:Patients with APS who were attending our lupus unit and who presented with se...

journal_title：Annals of the rheumatic diseases

authors： Castellino G,Cuadrado MJ,Godfrey T,Khamashta MA,Hughes GR

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVES:This prospective study was designed to clarify the frequency, causes, and clinical course of renal disease in patients with early rheumatoid arthritis (RA). METHODS:235 patients (185 women, mean age 49.4 years) with early RA of less than one year's duration were enrolled and assessed monthly. Proteinuria wa...

journal_title：Annals of the rheumatic diseases

authors： Koseki Y,Terai C,Moriguchi M,Uesato M,Kamatani N

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To study immunological markers and compare these markers with standard measures for the clinical and immunological follow up of vasculitis activity in hepatitis C virus (HCV) associated cryoglobulinaemic vasculitis (CV). METHODS:Serial serum samples from eight patients with newly diagnosed HCV associated CV ...

journal_title：Annals of the rheumatic diseases

authors： Lamprecht P,Moosig F,Gause A,Herlyn K,Csernok E,Hansen H,Gross WL

更新日期：2001-04-01 00:00:00

abstract：:The main goal of traditional treatment of idiopathic retroperitoneal fibrosis is limitation of morbidity, and surgery of already formed fibrous masses has been the main therapeutic approach. More recently, the knowledge that the disorder may be the result of an allergic reaction to atherosclerotic lipids has prompted ...

journal_title：Annals of the rheumatic diseases

authors： Marzano A,Trapani A,Leone N,Actis GC,Rizzetto M

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVES:To determine whether continued methotrexate treatment increases the risk of postoperative infections or of surgical complications in patients with rheumatoid arthritis (RA) within one year of elective orthopaedic surgery. DESIGN:A prospective randomised study of postoperative infection or surgical complicat...

journal_title：Annals of the rheumatic diseases

authors： Grennan DM,Gray J,Loudon J,Fear S

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:To elucidate factors involved in the arthritogenicity of bacterial cell walls. METHODS:For characterisation of an arthritogenic Eubacterium aerofaciens cell wall, peptidoglycan-polysaccharide (PG-PS) polymers were isolated by removing cell wall associated proteins (CWPs), PG and PS moieties were separated, a...

journal_title：Annals of the rheumatic diseases

authors： Zhang X,Rimpiläinen M,Simelyte E,Toivanen P

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:To determine if a new inhibitor, esculetin (EST), can block resorption of cartilage. METHODS:Interleukin 1alpha (IL1alpha, 0.04-5 ng/ml) and oncostatin M (OSM, 0.4-50 ng/ml) were used to stimulate the release of proteoglycan and collagen from bovine nasal cartilage and human articular cartilage in explant cu...

journal_title：Annals of the rheumatic diseases

authors： Elliott S,Rowan AD,Carrère S,Koshy P,Catterall JB,Cawston TE

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that ankylosing spondylitis (AS) is a T helper cell type 2 polarised disease by quantifying the T cell cytokines interferon gamma (IFNgamma), interleukin 4 (IL4), tumour necrosis factor alpha (TNFalpha), and IL10 at the single cell level in patients with AS in comparison with healthy HL...

journal_title：Annals of the rheumatic diseases

authors： Rudwaleit M,Siegert S,Yin Z,Eick J,Thiel A,Radbruch A,Sieper J,Braun J

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To clarify the deleterious effects of Mayer's haematoxylin staining procedure which result in a decrease in, or complete loss of, the number of calcium pyrophosphate dihydrate (CPPD) crystals, and to determine the proper staining period for preserving the crystals in a histological paraffin section of articul...

journal_title：Annals of the rheumatic diseases

authors： Ohira T,Ishikawa K

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:Validation of responsiveness and discriminative power of the World Health Organisation/International League of Associations for Rheumatology (WHO/ILAR) core set, the American College of Rheumatology (ACR), and European League for Rheumatology (EULAR) criteria for improvement/response, and other single and com...

journal_title：Annals of the rheumatic diseases

authors： Verhoeven AC,Boers M,van Der Linden S

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVES:(a) To characterise the lipid profile in psoriatic arthritis and investigate whether there are similarities to the dyslipoproteinaemia reported in rheumatoid arthritis and other inflammatory forms of joint disease; (b) to investigate whether there is an atherogenic lipid profile in psoriatic arthritis, which...

journal_title：Annals of the rheumatic diseases

authors： Jones SM,Harris CP,Lloyd J,Stirling CA,Reckless JP,McHugh NJ

更新日期：2000-11-01 00:00:00

abstract：:A novel, constitutively expressed and secreted interleukin 18 (IL18) binding protein (IL18BP) neutralises IL18. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited a...

journal_title：Annals of the rheumatic diseases

authors： Dinarello CA

更新日期：2000-11-01 00:00:00

abstract：:The success of anti-tumour necrosis factor (TNF) treatment, either using antibodies or soluble receptors, has defined TNF as a major factor of the inflammatory response in rheumatoid arthritis (RA). As a result of this success, much attention has been devoted to understanding the molecular mechanisms by which TNF expr...

journal_title：Annals of the rheumatic diseases

authors： Foxwell BM,Bondeson J,Brennan F,Feldmann M

更新日期：2000-11-01 00:00:00

abstract：:T cell activation and cellular immune responses are modulated by interleukin 2 (IL2) through binding to its corresponding cell surface receptor. Three forms of the receptor are recognised based on IL2 binding affinity. The high affinity receptor is a heterotrimer composed of alpha, beta, and gamma(c)-polypeptide chain...

journal_title：Annals of the rheumatic diseases

authors： Morris JC,Waldmann TA

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:To assess how socioeconomic deprivation influences the presentation, treatment, and outcome of patients with rheumatoid arthritis (RA). METHODS:Three year follow up of 869 consecutive patients with RA from nine hospital rheumatology clinics, with patients categorised by the Carstairs deprivation score of the...

journal_title：Annals of the rheumatic diseases

authors：

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVES:To forecast, on the basis of the past and present position of rheumatologists in Europe, the competence needed in the future to secure and promote the specialty within the healthcare network. METHODS:Union Européenne des Médecins Spécialistes/European Board of Rheumatology (UEMS/EBR) questionnaire on (a) tr...

journal_title：Annals of the rheumatic diseases

authors： Amor B

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the contribution of polymorphisms in the vitamin D receptor (VDR) gene to ethnic variations in bone mass in mother and children from different ethnic origins. METHODS:VDR genotypes and bone mass in 43 African-American and white women, mean age 38.2 years, and 41 of their children were studied. Al...

journal_title：Annals of the rheumatic diseases

authors： Nelson DA,Vande Vord PJ,Wooley PH

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVES:To examine objectively spatial patterns of osteophytes around the distal end of the femur and to identify distinct subgroups. METHODS:A sample of 107 human femora from a large skeletal population were selected for study. These femora included subjects with evidence of late stage osteoarthritis (that is, wit...

journal_title：Annals of the rheumatic diseases

authors： Shepstone L,Rogers J,Kirwan J,Silverman B

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:(1) To compare clinical outcome and symptomatology of rheumatoid cervical myelopathy between patients managed conservatively and surgically. (2) To determine if surgical outcome has improved since the series published from this unit in 1987. (3) To examine the role of magnetic resonance imaging (MRI) in the ...

journal_title：Annals of the rheumatic diseases

authors： Hamilton JD,Gordon MM,McInnes IB,Johnston RA,Madhok R,Capell HA

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVES:To study the pathogenesis of pneumomediastinum in polymyositis/dermatomyositis (PM/DM). PATIENTS AND METHODS:The clinical records of 48 patients with PM/DM were reviewed, focusing mainly on the presence of pneumomediastinum and cutaneous vasculopathy, and the chest radiographic changes. A patient with pneum...

journal_title：Annals of the rheumatic diseases

authors： Kono H,Inokuma S,Nakayama H,Suzuki M

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:To investigate the activation of NF-kappaB in the carrageenan rat air pouch model of inflammation in a time course experiment, and the effect of dexamethasone on NF-kappaB activation. METHODS:Air pouch tissue treated with carrageenan (inflamed tissue) was obtained from rats killed at days 1, 2, 3, 6, 14, 21,...

journal_title：Annals of the rheumatic diseases

authors： Ellis L,Gilston V,Soo CC,Morris CJ,Kidd BL,Winyard PG

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:Previously an upregulation of E-cadherin and its associated molecules alpha-catenin, beta-catenin and plakoglobin has been demonstrated in clinically overt inflammatory bowel disease (IBD). The aim of this study was to investigate the expression of the E-cadherin/catenin complex in subclinically inflamed bowe...

journal_title：Annals of the rheumatic diseases

authors： Demetter P,Baeten D,De Keyser F,De Vos M,Van Damme N,Verbruggen G,Vermeulen S,Mareel M,Elewaut D,Mielants H,Veys EM,Cuvelier CA

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:Sacroiliitis is a hallmark of the spondyloarthropathies (SpA). The degree of inflammation can be quantified by magnetic resonance imaging (MRI). The aim of this study was to further elucidate the pathogenesis of SpA by quantitative cellular analysis of immunostained sacroiliac biopsy specimens and to compare ...

journal_title：Annals of the rheumatic diseases

authors： Bollow M,Fischer T,Reisshauer H,Backhaus M,Sieper J,Hamm B,Braun J

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVES:Infectious agents like parvovirus have been implicated as exogenous factors that could trigger onset of systemic lupus erythematosus (SLE). A number of case reports describing a SLE-like presentation of acute human parvovirus B19 infection have been published, but no systematic investigation of the actual se...

journal_title：Annals of the rheumatic diseases

authors： Bengtsson A,Widell A,Elmstâhl S,Sturfelt G

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To investigate the sympathetic and parasympathetic cardiovascular function in primary Sjögren's syndrome (SS) and to investigate the possible relation with ocular dryness. METHODS:41 (40 women) patients with primary SS, mean age 50 years (range 20-80) with a mean disease duration of eight years (range 1-30),...

journal_title：Annals of the rheumatic diseases

authors： Barendregt PJ,van Den Meiracker AH,Markusse HM,Tulen JH,Boomsma F,van Der Heijde GL,Veld AJ

更新日期：1999-12-01 00:00:00

abstract：:Progress in understanding mechanisms of disease are necessary to usher in major changes in treatment. A new era in rheumatoid arthritis (RA) and related chronic autoimmune/inflammatory diseases is now beginning, with a variety of anti-TNFalpha treatments licensed for use in both RA and Crohn's disease. The rationale f...

journal_title：Annals of the rheumatic diseases

authors： Feldmann M,Bondeson J,Brennan FM,Foxwell BM,Maini RN

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVES:To study long term utility of early, continual, and serial use of disease modifying antirheumatic drugs (DMARDs) in early rheumatoid arthritis (RA) in clinical setting. METHODS:A total of 135 patients with early RA were treated according to the "sawtooth" strategy and prospectively followed up to 15 years. ...

journal_title：Annals of the rheumatic diseases

authors： Sokka T,Hannonen P

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:Advances in health measurement have led to the application of Rasch Item Response Theory (IRT) analysis (Rasch analysis) to evaluate instruments measuring health status and quality of life of patients, including the Health Assessment Questionnaire and SF-36. This study investigated the extent to which the Wes...

journal_title：Annals of the rheumatic diseases

authors： Wolfe F,Kong SX

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVES:The use of silicone implants in cosmetic and reconstructive surgery has been implicated in the development of autoimmune connective tissue diseases. Previous investigation of the influence of short-term silicone implantation using an experimental model of rheumatoid arthritis revealed no adverse influence up...

journal_title：Annals of the rheumatic diseases

authors： Schaefer CJ,Lawrence WD,Wooley PH

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:To investigate whether type II collagen (CII) is recognised by oligoclonally expanded synovial T cells of patients with rheumatoid arthritis (RA). METHODS:Peripheral blood mononuclear cells (PBMC) from 15 RA patients were stimulated with CII in vitro. T cell clones expanded by such stimulation were compared ...

journal_title：Annals of the rheumatic diseases

authors： Sekine T,Kato T,Masuko-Hongo K,Nakamura H,Yoshino S,Nishioka K,Yamamoto K

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVES:Chondrocytic matrix metalloproteinases (MMPs) are believed to be important in osteoarthritic cartilage degradation. The cartilage lesion of osteoarthritis (OA) is focal and often progressive. During its development chondrocytes differentially up and down regulate production of mRNA for individual MMPs. This ...

journal_title：Annals of the rheumatic diseases

authors： Freemont AJ,Byers RJ,Taiwo YO,Hoyland JA

更新日期：1999-06-01 00:00:00

abstract：OBJECTIVES:To assess the interobserver agreement on the diagnostic classification of shoulder disorders, based on history taking and physical examination, and to identify the determinants of diagnostic disagreement. METHODS:Consecutive eligible patients with shoulder pain were recruited in various health care settings...

journal_title：Annals of the rheumatic diseases

authors： de Winter AF,Jans MP,Scholten RJ,Devillé W,van Schaardenburg D,Bouter LM

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVES:To investigate the potential clinical benefit of a combination therapy. METHODS:205 patients fulfilling the ACR criteria for rheumatoid arthritis (RA), not treated with disease modifying antirheumatoid drugs previously, with an early (< or = 1 year duration), active (Disease Activity Score (DAS) > 3.0), rhe...

journal_title：Annals of the rheumatic diseases

authors： Dougados M,Combe B,Cantagrel A,Goupille P,Olive P,Schattenkirchner M,Meusser S,Paimela L,Rau R,Zeidler H,Leirisalo-Repo M,Peldan K

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVES:Factors contributing to the development of systemic lupus erythematosus (SLE) remain largely unknown although are likely to include both environmental and genetic components. Studies on murine lupus have indicated a role for an antibody that blocks binding of cytotoxic T lymphocyte associated-4 (CTLA-4) to B...

journal_title：Annals of the rheumatic diseases

authors： Heward J,Gordon C,Allahabadia A,Barnett AH,Franklyn JA,Gough SC

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVES:To determine the difference in shape of the distal femur, viewed axially in two dimensions, between eburnated and non-eburnated femora. METHODS:A comparison of 52 non-eburnated and 16 eburnated femora drawn from a large archeological skeletal population. Eburnation was taken to indicate late stage osteoarth...

journal_title：Annals of the rheumatic diseases

authors： Shepstone L,Rogers J,Kirwan J,Silverman B

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:To report the efficacy of conservative treatment with cervical traction and immobilisation with a Halo vest, in two consecutive rheumatoid arthritis patients with progressive cervical myelopathy caused by subaxial subluxation. METHODS:Description of neurological symptoms and signs and findings in plain radio...

journal_title：Annals of the rheumatic diseases

authors： Oostveen JC,van de Laar MA,Geelen JA,de Graaff R

更新日期：1999-02-01 00:00:00